ESPACE – the expression and spatial analysis pancreas atlas consortium europe
ESPACE – the HCA pancreas initiative
The Human Cell Atlas (HCA) is a global initiative which will create molecular reference maps of all human cells.
Three prior HCA early pilot studies of the pancreas came together to form the “Expression and Spatial analysis Pancreas Atlas Consortium Europe”, ESPACE.
Based on methods and standards for sample procurement, single cell profiling, spatial proteomics, and computational pipelines that were developed in these pilot studies, the ESPACE consortium built a first version of the Human Cell Atlas of the Pancreas. In total, six projects had been selected for funding by the European Commission, each working on a different organ, and delivered their contributions to the HCA in 2022.
Core activities overview
WP1 Tissue groups and sample procurement
Lead: Leiden University Medical Center (LUMC)
WP2 Single cell molecular profiling of the healthy human pancreas
Lead: Centre for Genomic Regulation (CRG)
WP3 Single cell molecular profiling of islets from T2D patients
Lead: The Research Fund of Hadassah Medical Organization (RFHMO)
WP4 Spatial analysis of cells and cell identity genes
Lead: Kungliga Tekniska Hoegskolan (KTH)
WP5 Data management – DCP Pancreas
Lead: Charité – Universitaetsmedizin Berlin (Charité)
WP6 Project management & Dissemination
Lead: Charité – Universitaetsmedizin Berlin (Charité)
